Telomere dysfunction has been proposed as a key event that causes cancer progression. According to this model, progressive telomere shortening results in telomere dysfunction and end-to-end chromosomal fusions. The resulting … Continue Reading Researchers identify telomere-based mechanism which turns mutant cells into aggressive cancers.
Antigen receptor genes are assembled by controlled, large-scale deletions and inversions. Errors in this process, known as V(D)J recombination, produce aberrant genomic rearrangements, which can fuel the development of T- … Continue Reading Researchers identify points where incorrect immune cell DNA editing causes blood cancer.
Natural killer cells of the immune system can fend off malignant lymphoma cells and thus are considered a promising therapeutic approach. However, previous studies show that in the direct vicinity … Continue Reading Researchers identify how lymphoma tumours evade the immune response.
The first-ever systematic study of the genomes of patients with ALK-negative anaplastic large cell lymphoma (ALCL), a particularly aggressive form of non-Hodgkin’s lymphoma, shows that many cases of the disease … Continue Reading Researchers demystify rare, deadly lymphoma.
A new study of acute lymphoblastic leukemia (ALL), a blood cancer that primarily affects young children, has revealed that the disease has two distinct subtypes, and provides preliminary evidence that … Continue Reading Precision medicine study reveals new subtype of childhood leukemia.
Scientists from the CNRS, INSERM and Université de Limoges have demonstrated that the production of type E immunoglobulins (IgE)2 by B lymphocytes induces a loss in their mobility and the … Continue Reading Researchers map programmed cell death in immune cells to prevent allergy.