Much work is being done on human limb regeneration concentrating on the specific microRNA circuit used by zebrafish, bichirs, and axolotls to regulate the regrowth of amputated extremities. Unfortunately, humans … Continue Reading Humans have the salamander-like ability to regenerate cartilage in joints.
Preterm birth is a leading cause of infant mortality that can lead to poor life-long health and adverse neurodevelopmental outcomes. The physiologic mechanisms that precede preterm labor remain elusive, and … Continue Reading Epigenetics and environmental factors identified in preterm birth.
Ebola virus disease (EVD) is a severe infectious disease which caused an epidemic in West Africa in 2013-2015, and has resulted in at least 10,000 confirmed deaths. Early diagnosis of … Continue Reading Cell-free microRNA identified as biomarker for early diagnosis of Ebola.
Autism Spectrum Disorders (ASD) are a group of highly inheritable behavioural disorders. Patients with ASD have mild to severe communication difficulties, repetitive behaviour and social challenges. Such disorders significantly challenge … Continue Reading Study identifies neurogenetics that link abnormal neurodevelopment to ASD.
It is known that chronic inflammation in the gut increases the risk of colon cancer by as much as 500%. Therefore, the genetic basis and mechanism of cancer proliferation in … Continue Reading Researchers show how gut inflammation initiates colon cancer.
To better understand diseases with a genetic component, a popular approach is to take skin cells from patients with a disease and use enzymes to coax the cells back along … Continue Reading Researchers successfully develop leukemia-in-a-dish.
After it is transcribed from DNA, RNA can go on to many fates. While the most familiar path may lead directly to the production of protein, RNA molecules themselves can … Continue Reading Researchers unlock another piece of the RNA sequencing puzzle.
A glioma is a type of tumour that starts in the brain or spine. It is called a glioma because it arises from glial cells. The most common site of … Continue Reading First ever study shows how astrocytes help to spread glioma.
A novel blood test could greatly improve triage of victims of radiation accidents by rapidly predicting who will survive, who will die, and who should receive immediate medical countermeasures, according … Continue Reading New RNA-based blood test quickly reveals severity of radiation injury.
A molecular switch that seems to be essential for embryonic heart cells to grow into more mature, adult-like heart cells has been discovered by researchers at University of Washington. The … Continue Reading Researchers identify the molecular switch that promotes heart cell maturation.
The micro RNA miR-22 has long been known for its ability to suppress cancer. However, questions remain about how it achieves this feat. For example, which molecules are regulating miR-22, … Continue Reading Researchers being to map the epigenetic pathway of miR-22 cancer suppression.
The heart tissue of mammals has limited capacity to regenerate after an injury such as a heart attack, in part due to the inability to reactivate a cardiac muscle cell … Continue Reading Researchers induce microRNA-based cardiomyocyte proliferation after heart attack in animal model.
In the battle between a cell and a virus, either side may resort to subterfuge. Molecular messages, which control the cellular machinery both sides need, are vulnerable to interception or … Continue Reading Researchers map microRNA’s role in the human hepatitis c infection.
In what is believed to be the largest epigenetic analysis to date of cell-signaling molecules in early-stage melanoma, researchers at NYU Langone Medical Center have identified two tiny bits of … Continue Reading Largest ever analysis maps epigenetic methylation pathway which suppresses the spread of melanoma.
Cancers that have spread throughout the body, a process known as metastasis, are difficult, often impossible, to control. They are the leading cause of cancer-related deaths. Twenty years ago, however, … Continue Reading Researchers use precision medicine-based microRNAs to limit cancer metastases.