Abnormalities in human airway smooth muscle cell function and structure play critical roles in chronic inflammatory airway diseases, such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis. One key … Continue Reading Olfactory receptors discovered in human bronchi.
It is known that skeletal muscle regeneration is impaired in age-related diseases such as sarcopenia, which is marked by reduced muscle regenerative capacity with aging, due in part to a … Continue Reading Study identifies gene responsible for regeneration of injured muscle by adult stem cells.
In Kennedy’s disease, the muscle cells and motor neurons, which are also linked to muscle function, are damaged as a result of the accumulation of androgen receptor fibers, a process … Continue Reading Identification of a neuroprotector linked to a degenerative neuromuscular disease.
During exercise, muscle function needs to significantly increase; this requires that the uptake and breakdown of the two main nutrients of myofibers, glucose and fatty acids (FAs), markedly rise. The … Continue Reading First ever bone-derived hormone to affect exercise capacity identified.
Heart failure is one of the main health problems worldwide, and the urgent medical needs relating to it have positioned cardiovascular research as one of the most actively evolving fields … Continue Reading Study links adult heart regeneration to telomere length in animal model.
In humans, up to half of body mass is made up of skeletal muscle, which plays a key role in locomotion, posture, and breathing. Although skeletal muscles can overcome minor … Continue Reading Biologic-free mechanically induced muscle regeneration successful in animal studies.
Mammalian skeletal muscles can regenerate following injury and this response is mediated by a specific type of stem cell, the satellite cell. Significant evidence suggests that while stem cells represent … Continue Reading Previously unknown mechanism in skeletal muscle regeneration identified.
The muscular dystrophies are a group of muscle wasting disorders characterized by progressive weakening and degeneration of striated muscle. The most common form is Duchenne muscular dystrophy (DMD), an X-linked … Continue Reading New treatment strategy for muscular dystrophy sound in preclinical phase.
As humans grow older, they lose strength and muscle mass. Skeletal muscle weakness and atrophy are among the most pervasive and disruptive effects of aging. In nearly all people, even … Continue Reading Researchers identify precise cause of muscle weakness and loss due to aging.
Heart regeneration a step closer as researchers identify progenitor cell exclusively for heart muscle.
Future therapies for failing hearts are likely to include stem-like cells and associated growth factors that regenerate heart muscle. Now, researchers from the University of Pennsylvania have just taken an … Continue Reading Heart regeneration a step closer as researchers identify progenitor cell exclusively for heart muscle.
Diabetic neuropathy is a condition in which perpetually high blood sugar causes nerve damage, resulting in a myriad of symptoms such as numbness, reduced ability to detect painful stimuli, muscle … Continue Reading Stem cell injections improve diabetic neuropathy in animal models.
Researchers have long wondered what causes people to lose muscle strength as they age and how exercise can prevent it from happening. Now, McMaster University researchers have discovered a key … Continue Reading Researchers identify protein required to maintain muscle mass and strength during aging.
The heart tissue of mammals has limited capacity to regenerate after an injury such as a heart attack, in part due to the inability to reactivate a cardiac muscle cell … Continue Reading Researchers induce microRNA-based cardiomyocyte proliferation after heart attack in animal model.
Researchers from the UC San Diego and the University of Iowa have identified a key piece in the complex molecular puzzle underlying heart failure, a serious and sometimes life-threatening disorder affecting more … Continue Reading Researchers identify protein responsible for epigenetic change in heart failure.
The average heart beats 35 million times a year, 2.5 billion times over a lifetime. Those beats must be precisely calibrated; even a small divergence from the metronomic rhythm can … Continue Reading Researchers identify protein responsible for keeping the heart beating on time.
After an incomplete spinal cord injury, the body can partially recover basic motor function. So-called muscle spindles and associated sensory circuits back to the spinal chord promote the establishment of … Continue Reading Trigger mechanism for recovery after spinal cord injury identified.