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New hope for treatment of Alzheimer’s disease.

Researchers from the Douglas Mental Health Institute and McGill University have discovered that a relatively frequent genetic variant actually conveys significant protection against the common form of Alzheimer’s disease and … Continue Reading New hope for treatment of Alzheimer’s disease.

Discovery of new drug targets for memory impairment in Alzheimer’s Disease.

Discovery of new drug targets for memory impairment in Alzheimer’s Disease. A study from KIST has revealed the novel mechanism of how Alzheimer’s patients might lose their memory. The researchers also propose new therapeutic targets, which include GABA production and release mechanisms in reactive astrocytes for treatment of Alzheimer’s disease. Furthermore, we provide a stepping stone for the development of MAO-B inhibitors with long lasting efficacy.

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Study cracks how the brain processes emotions.

Study cracks how the brain processes emotions. Researchers have discovered that fine-grained patterns of neural activity within the orbitofrontal cortex, an area of the brain associated with emotional processing, act as a neural code which captures an individual’s subjective feeling. The findings provide insight into how the brain represents the human’s innermost feelings, what neuroscientists are calling the last frontier of neuroscience, and upend the long-held view that emotion is represented in the brain simply by activation in specialized regions for positive or negative feelings.

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Study shows link between inflammation in maternal blood and schizophrenia in offspring.

Maternal inflammation as indicated by the presence in maternal blood of early gestational C-reactive protein, an established inflammatory biomarker, appears to be associated with greater risk for schizophrenia in offspring. Inflammation has been shown to alter brain development in previous studies, and schizophrenia is a neurodevelopmental disorder. Thus, this study provides an important link between inflammation and schizophrenia and may help the medical community to better understand the biological mechanisms that lead to this disorder.

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Brain tumour invasion along blood vessels may lead to new cancer treatments.

NIH-funded researchers map brain tumour cells disrupting the blood-brain barrier, offering potential avenues for therapy. Invading glioblastoma cells may hijack cerebral blood vessels during early stages of disease progression and damage the brain’s protective barrier, a study in mice indicates. This finding could ultimately lead to new ways to bring about the death of the tumour, as therapies may be able to reach these deadly cells at an earlier time point than was previously thought possible.

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