Parkinson’s disease (PD) is a long-term neurodegenerative disorder of the central nervous system whose symptoms generally come on slowly over time, mainly affecting the motor system. The most common genetic … Continue Reading Scientists identify a role for main Parkinson’s gene in the brain.
Study shows that structure of toxic tau aggregates determines type of dementia, and rate of progression.
Recent efforts to develop a treatment for Alzheimer’s disease and other dementias have focused heavily on removing toxic tau proteins from the brain. The tau protein is known to bind … Continue Reading Study shows that structure of toxic tau aggregates determines type of dementia, and rate of progression.
It is known that Parkinson’s disease, the second most common neurodegenerative disease, has genetic causes in 15% of cases. It has been shown that premature aging of dopaminergic neurons in the … Continue Reading Study shows how defective gene prematurely ages neurons in Parkinson’s disease.
Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease affecting motor neurons. This fatal disease is characterized by progressive muscular atrophy and doesn’t have an effective treatment. Patients with … Continue Reading Study provides first definitive evidence and description of protein clump toxicity in ALS.
Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. While aggressive familial early … Continue Reading New technique enables researchers to grow old human brain cells for the first time.
Scientists from the Gladstone Institutes and the University of Michigan have identified a cellular mechanism that can be targeted to treat ALS. The researchers discovered that increasing levels of a … Continue Reading Researchers identify previously unknown neuroprotective pathway in ALS.
By adjusting the levels of a key signaling protein, researchers from The Children’s Hospital of Philadelphia (CHOP) improved motor function and brain abnormalities in experimental animals with a form of … Continue Reading Scientists reverse Huntington’s disease in animal model using precision medicine.
Using an innovative technique combining genetic analysis and mathematical modeling, researchers from the University of Illinois at Chicago College of Medicine, Wayne State University and Montana State University have identified previously … Continue Reading ‘Microlesions’ in epilepsy discovered by novel neurogenetic technique.
Genetics may play a larger role in causing Lou Gehrig’s disease than previously believed, potentially accounting for more than one-third of all cases, according to one of the most comprehensive … Continue Reading New neurogenetic origins of Lou Gehrig’s disease uncovered.
Scientists from The Scripps Research Institute (TSRI) have uncovered a major contributor to Huntington’s disease, a devastating progressive neurological condition that produces involuntary movements, emotional disturbance and cognitive impairment. Using … Continue Reading Scientists uncover master key in development of Huntington’s Disease.
People with multiple sclerosis (MS) lose myelin in the grey matter of their brains and the loss is closely correlated with the severity of the disease, according to a new … Continue Reading New neuroimaging technique links grey matter myelin loss to severity of MS.
Stimulating a particular region in the brain via non-invasive delivery of electrical current using magnetic pulses, called Transcranial Magnetic Stimulation, improves memory, reports a new Northwestern Medicine study. The discovery … Continue Reading Transcranial Magnetic Stimulation (TMS) successfully improves memory.
Scientists at the University of Warwick have provided the first evidence that the lack of a naturally occurring protein is linked to early signs of dementia. The research found that … Continue Reading Lack of naturally occurring protein linked to dementia.
Researchers have long suspected that major mental disorders are genetically-rooted diseases of synapses, the connections between neurons. Now, investigators from Johns Hopkins University have demonstrated in patients’ cells how a … Continue Reading Suspect gene corrupts neural connections.
Two years ago, the parents of Chloe Olivarez watched painfully as their daughter experienced epileptic seizures hundreds of times a day. The seizures, caused by a rare metabolic disease that … Continue Reading Precursor reduces debilitating epileptic seizures.
Vitamin D deficiency is associated with a substantially increased risk of dementia and Alzheimer’s disease in older people, according to the most robust study of its kind ever conducted. An … Continue Reading Link between vitamin D and dementia risk confirmed.