Morphine mediates its euphoric and analgesic effects by acting on the μ-opioid receptor (MOR). MOR belongs to the family of G-protein coupled receptors whose signaling efficiency is controlled by the … Continue Reading Researchers identify key morphine regulator in the brain.
In the treatment of pain, a common course is to treat patients with opioid medications, these medications show limited effectiveness for neuropathic pain and come with safety and addiction issues. … Continue Reading Researchers map how antidepressants lessen neuropathic pain.
Researchers successfully implant and control light-sensitive opioid receptors in mice via optogenetics.
Despite the abuse potential of opioid drugs, they have long been the best option for patients suffering from severe pain. The drugs interact with receptors on brain cells to tamp … Continue Reading Researchers successfully implant and control light-sensitive opioid receptors in mice via optogenetics.
In a new study from Saint Louis University, researchers discovered that drugs targeting the A3 adenosine receptor can turn off pain signals in the spinal cord to provide relief from … Continue Reading Researchers use A3 adenosine receptors to activate ‘off signals’ for chronic pain.
Researchers at Aalto University and University of Turku have revealed how obesity is associated with altered opioid neurotransmission in the brain. New research reveals how obesity is associated with altered … Continue Reading Neuroimaging study maps brain neurotransmission system involved in obesity.
New research from The University of Queensland shows that seven compounds of the countless found in spider venom block a key step in the body’s ability to pass pain signals … Continue Reading Analysis of spider venom reveals multiple compounds with potential to relieve chronic pain.
Within a few months after drug withdrawal, patients in recovery from dependence on prescription pain medications may show signs that the body’s natural reward systems are normalizing. The study from … Continue Reading Researchers map clinical neuroimaging markers for opioid withdrawal.