Telomere dysfunction has been proposed as a key event that causes cancer progression. According to this model, progressive telomere shortening results in telomere dysfunction and end-to-end chromosomal fusions. The resulting … Continue Reading Researchers identify telomere-based mechanism which turns mutant cells into aggressive cancers.
An important mystery has been why some cells in the body already have mutations seen in cancer, yet do not fully behave like the cancer. Now, researchers led by the … Continue Reading In a world’s first, researchers image the origins of cancer from the first affected cell.
Antigen receptor genes are assembled by controlled, large-scale deletions and inversions. Errors in this process, known as V(D)J recombination, produce aberrant genomic rearrangements, which can fuel the development of T- … Continue Reading Researchers identify points where incorrect immune cell DNA editing causes blood cancer.
Scientists from the Spanish National Cancer Research Centre (CNIO) have discovered a new strategy to fight cancer, which is very different from those described to date. Their work shows for … Continue Reading Researchers have successfully ‘uncapped’ telomeres in animal lung cancer model.
A common, yet previously undistinguished protein, which is elevated in many late-stage cancers, may play a strategic role in tumour growth through a non-conventional pathway, researchers at the Indiana University … Continue Reading Researchers identify previous unknown pathway for p53 cancer cell activation.
Case Western Reserve researchers have identified a two-pronged therapeutic approach that shows great potential for weakening and then defeating cancer cells. The team’s complex mix of genetic and biochemical experiments … Continue Reading Cancer treatment identified in gene repair pathway.