Our onboard computer, the brain, is a sterile environment separated from the immune system by the blood-brain barrier (BBB), which is why it has its own resident immune cells, known … Continue Reading New role for white blood cells in the developing brain.
Parkinson’s disease (PD) is a long-term neurodegenerative disorder of the central nervous system whose symptoms generally come on slowly over time, mainly affecting the motor system. The most common genetic … Continue Reading Scientists identify a role for main Parkinson’s gene in the brain.
Parkinson’s disease is a progressive neurodegenerative disorder exhibiting far-reaching clinical manifestations, with recent research focusing on gut-brain interactions involving the gut microbiota. However, researchers understand little about the link between … Continue Reading Pre-clinical study suggests Parkinson’s could start in the gut.
It is known that rigidity and loss of muscle function associated with Parkinson’s is linked to a depletion of dopamine in the part of the brain that controls movement. However, … Continue Reading Gene mutation identified for early onset of Parkinson’s disease in Caucasians.
Stem cell treatments for neurodegenerative diseases are expected to reach clinical trials soon. One major task en route to the clinic is to generate standardized good manufacturing practice (GMP)-grade human-pluripotent … Continue Reading Breakthrough in the production of dopamine neurons for Parkinson’s disease.
The CDC estimates that more than 1.3 million Americans visit an emergency department each year because of a TBI-related injury. The late effects of TBI are of great interest, however, … Continue Reading Largest ever study identifies link between TBI and Parkinson’s, but not Alzheimer’s.
Parkinson’s disease (PD) is a degenerative neurological disease characterized by tremor, slowness, and gait and balance difficulties that affects approximately 1 million people in the United States. The symptoms are … Continue Reading Study identifies key to Parkinson’s disease neurodegeneration.
In patients with Parkinson’s disease, gait disorders and difficulty with balance are often caused by the degeneration of a specific type of neuron, called cholinergic neurons, in a region of … Continue Reading New technique begins to map and untangle neuronal networks in Parkinson’s disease.
With Parkinson’s disease clinicians have long noted that the presence of tremors, rather than balance and walking problems is the initial or dominant symptom and hypothesize this may even suggest … Continue Reading Human study identifies genetic variation for type and rate of physical decline Parkinson’s disease.
It is known that Parkinson’s disease, the second most common neurodegenerative disease, has genetic causes in 15% of cases. It has been shown that premature aging of dopaminergic neurons in the … Continue Reading Study shows how defective gene prematurely ages neurons in Parkinson’s disease.
It’s long been known that excess iron is found in the brains of patients with Parkinson’s disease (PD), an incurable neurodegenerative condition that affects motor function. However, the mechanism by … Continue Reading Researchers identify the neurogenetic basis of excess iron in Parkinson’s disease.
An estimated seven to ten million people worldwide are living with Parkinson’s disease (PD), which is an incurable and progressive disease of the nervous system affecting movement and cognitive function. … Continue Reading Study first to link immunogenetics to non-familial Parkinson’s disease.
The blood-brain barrier represents a fundamental limitation in treating neurological disease because it prevents all neuropeptides from reaching the central nervous system (CNS). Currently, there is no efficient method to … Continue Reading New technique bypasses the blood-brain barrier to deliver neuroprotection.
Dopamine deficiency in the basal ganglia is known to cause severe motor dysfunctions such as slowness of movement, or bradykinesia, as seen in Parkinson’s disease. Dopamine binds D1 and D2 receptors … Continue Reading Study identifies the cause of slowness of movement in Parkinson’s disease.
Parkinson’s disease (PD) belongs to a group of conditions called motor system disorders, which are the result of the loss of dopamine-producing brain cells. The four primary symptoms of PD … Continue Reading Study shows magnetic stimulation effectively treats frozen gait in Parkinson’s.
Much like a community’s network for garbage handling, cells also have garbage sites called lysosomes, where proteins, which are functioning badly because of age or other reasons, go for degradation … Continue Reading Study links two proteins that help cells eliminate trash to Parkinson’s disease.