In adult reproduction daily oral contraceptive pills provide women with a means to avoid pregnancy which can support their health and economical situation. For oral contraception to be effective, consistent … Continue Reading Once-a-month oral contraceptive pill developed.
Recent progress in synthetic biology offers the potential to optimize the production of virtually any compound, as well as the development of previously unknown ones. Engineered synthetic biological systems are … Continue Reading Intelligent cells improve production of pharmaceutical raw materials.
Proteins hold enormous promise to treat chronic conditions and irreversible injuries, for example, human growth hormone is encapsulated in tiny polymeric particles and used to treat children with stunted growth. … Continue Reading First ever system can control protein release from nanoparticles without encapsulation.
The human immunodeficiency virus (HIV) is a lentivirus which causes HIV infection and over time AIDS. Developing effective prevention measures for HIV is hindered by incomplete knowledge of the phenotype … Continue Reading New technology lights up location of first cells to be infected in female HIV transmission.
Type 1 diabetes is an autoimmune disease, meaning that the underlying problem is with the immune system. It is still unclear as to why the body’s immune system attacks and … Continue Reading Salmonella-based oral vaccine for T1 diabetes successful in animal model.
Being able to detect early on whether a cancer therapy is working proffers obvious benefits for therapy-outcomes whilst influencing the course of treatment and improving the quality of life for … Continue Reading Novel ‘reporter’ nanoparticle reveals cancer treatment effectiveness in real-time.
Envelope glycoprotein GP120 is a glycoprotein exposed on the surface of the HIV envelope (ENV). The envelope glycoprotein trimer is essential for HIV entry into cells as it plays a … Continue Reading New breakthrough imaging shows HIV structure in unprecedented detail.
In recent years, Ebola outbreaks have increased in frequency, duration, and geographical spread, underscoring the need for pre- and post-exposure treatments. Antibodies targeting the Ebola virus surface glycoprotein, the viral structure … Continue Reading Previously unknown ebola-fighting antibodies identified in outbreak survivor’s blood.
Synthetic biology uses natural molecules and assembles them into a system that acts unnaturally. The ability to control the transfer of molecules through cellular membranes is an important function in … Continue Reading New ‘nanoneedles’ puncture cell membrane to release payload on command.
The liver plays a critical role in how the body metabolizes drugs and produces key proteins. This is why liver models are increasingly being developed in the lab as platforms … Continue Reading Researchers successfully 3D-print biomimetic liver tissue for drug screening.
Expanded use of engineered nanoparticles in consumer products and drug delivery increases the potential for environmental release, overexposure or unintended biological exposure. As a result, extraction techniques with integrated measurement … Continue Reading New technique can remove nanoparticles unaltered from blood with ease.
Limb Girdle Muscular Dystrophy is caused by mutations in any of at least 15 different genes and affects 1 in 14,500 to 1 in 123,000 annually. Individuals with Limb Girdle … Continue Reading Precision medicine for severe muscular dystrophy heads for clinical trials.
DNA methylation is essential for the proper control of gene expression and cell identity, what enables cells with the same genetic material to become, for example, a nerve cell, a … Continue Reading Single-cell imaging developed which can record DNA methylation in real time.
Statins are a popular and easy-to-swallow option for people looking to lower their cholesterol. However, for a quarter of patients, statins come with muscle pain, stiffness, cramps, or weakness without … Continue Reading Researchers link statins to disruption of muscle mitochondria.
Morphine mediates its euphoric and analgesic effects by acting on the μ-opioid receptor (MOR). MOR belongs to the family of G-protein coupled receptors whose signaling efficiency is controlled by the … Continue Reading Researchers identify key morphine regulator in the brain.
Premature birth is the birth of a baby at less than 37 weeks gestational age. Risk factors include diabetes, high blood pressure, being pregnant with more than one baby, being … Continue Reading Researchers identify a molecule which prevents preterm birth/labour.