In the female reproductive system ovarian follicles are the basic unit of the ovary, consisting of an immature egg, known as an oocyte, surrounded by granulosa cells. Besides being crucial … Continue Reading Mice born from eggs derived from the granulosa cells surrounding oocytes.
Many ethical, as well as supply issues, surround the use of human brain tissue in research, because of this stem cells are used to develop mini-brains or ‘organoids’, a pea-sized … Continue Reading Brain waves detected in lab-grown mini brains.
Stem cell treatments for neurodegenerative diseases are expected to reach clinical trials soon. One major task en route to the clinic is to generate standardized good manufacturing practice (GMP)-grade human-pluripotent … Continue Reading Breakthrough in the production of dopamine neurons for Parkinson’s disease.
Telomeres are critical for maintaining genomic integrity with telomere dysfunction or shortening commonly acquired during the process of tumour development. To add to this cancer cells require a mechanism to … Continue Reading Mystery solved as protein expressed in response to telomere shortening identified.
Irreversible degeneration of the cardiac conduction system is a common disease with high rates of mortality. While electronic pacemakers provide effective treatment, alternative approaches are needed with long-term implanted hardware … Continue Reading Extensive lit review performed on harnessing stem cells to generate biological pacemakers.
In the field of iPS cell-based regenerative medicine, advanced research with clinical applications for many organs and tissues, such as the retina, has steadily progressed. However, growing a kidney from … Continue Reading Human stem cell-derived kidneys connect to blood vessels when transplanted into mice.
In human blood formation, everything begins with the stem cell, which is the executive decision-maker quickly driving the process that replenishes blood at a daily rate that exceeds 300 billion … Continue Reading Researchers redefine how blood is made.
Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. While aggressive familial early … Continue Reading New technique enables researchers to grow old human brain cells for the first time.
To better understand diseases with a genetic component, a popular approach is to take skin cells from patients with a disease and use enzymes to coax the cells back along … Continue Reading Researchers successfully develop leukemia-in-a-dish.
The heart is arguably the hardest working muscle in the human body and without its incessant, regular beating the body’s organs would be starved of life-giving nutrients. Yet how the … Continue Reading Researchers identify precision medicine for the development of healthy heart muscle.
Pre-eclampsia is a disease that affects 5 to 8 percent of pregnancies in America. Complications from this disease can lead to emergency cesarean sections early in pregnancies to save the … Continue Reading Researchers discover previously unknown transitional stem cell.
An injection of stem cells into the eye may soon slow or reverse the effects of early-stage age-related macular degeneration, according to new research from scientists at Cedars-Sinai. Currently, there … Continue Reading Stem cell injection reverses vision loss due to age-related macular degeneration in animal model.
Researchers show for the first time that mitochondria are altered in human model of Parkinson’s disease.
It has long been suspected that the most common mutation linked to both sporadic and familial Parkinson’s disease wreaks its havoc by altering the function of mitochondria in neurons that … Continue Reading Researchers show for the first time that mitochondria are altered in human model of Parkinson’s disease.
Healthy bone is continuously involved in a dynamic process that includes bone deposition and bone resorption. However, when a person has cancer that spreads to the bone and bone marrow, … Continue Reading Researchers identify new role for cytokine VEGFA in the metastasis of neuroblastoma.
For infants with severe combined immunodeficiency (SCID), something as simple as a common cold or ear infection can be fatal. Born with an incomplete immune system, kids who have SCID, … Continue Reading Researchers grow and correct an SCID immune system in-a-dish via precision medicine.
In 1953 Watson and Crick first published the discovery of the double helix structure of the DNA. They were able to visualize the DNA structure by means of X-Ray diffraction. … Continue Reading Researchers image and count nucleosomes in the human genome for the first time ever.