Telomeres are our own personal inbuilt clock found at the end of chromosomes dictating how and when we age, with these protective caps ensuring no damage comes to the DNA … Continue Reading Researchers identify previously unknown telomere-specific protein.
Nanomachines made from synthetic DNA motors have the potential to mimic natural protein motors in cells, however, the operation of synthetic DNA motors in living corpuscles has not yet been … Continue Reading Autonomous nanomachines perform biologic functions in live cells.
Study shows that structure of toxic tau aggregates determines type of dementia, and rate of progression.
Recent efforts to develop a treatment for Alzheimer’s disease and other dementias have focused heavily on removing toxic tau proteins from the brain. The tau protein is known to bind … Continue Reading Study shows that structure of toxic tau aggregates determines type of dementia, and rate of progression.
Alzheimer’s disease is a neurodegenerative disorder characterized by progressive memory loss and cognitive dysfunction. It affects more than 30 million people worldwide, including an estimated 5.4 million Americans. One in … Continue Reading Dysfunction in neuronal transport mechanism linked to Alzheimer’s disease.
Alzheimer’s disease is characterized by the degeneration of neurons in the hippocampus and cortex, and the appearance of neuritic plaques and neurofibrillary tangles. Although the precise cause of Alzheimer’s disease remains … Continue Reading Researchers elevate brain protein to allay symptoms of Alzheimer’s in animal model.
For decades, scientists have known that people with two copies of a gene called apolipoprotein E4, or ApoE4, are much more likely to have Alzheimer’s disease at age 65 than … Continue Reading Study shows why people with the ApoE4 gene are more susceptible to Alzheimer’s disease.
Patients suffering from so-called immune-mediated neuropathies frequently have a long medical record. As there are no diagnostic tests available to reliably diagnose the disease, the diagnosis is frequently made belatedly … Continue Reading Study identifies previously unknown cause of immune neuropathy.
In Kennedy’s disease, the muscle cells and motor neurons, which are also linked to muscle function, are damaged as a result of the accumulation of androgen receptor fibers, a process … Continue Reading Identification of a neuroprotector linked to a degenerative neuromuscular disease.
Parkinson’s disease (PD) is a degenerative neurological disease characterized by tremor, slowness, and gait and balance difficulties that affects approximately 1 million people in the United States. The symptoms are … Continue Reading Study identifies key to Parkinson’s disease neurodegeneration.
There has been much focus on how to prevent heart disease by regulating the secretion of very low density lipoproteins (VLDL) by the liver. These lipoproteins are known to increase … Continue Reading Study shows damage to previously unknown liver protein leads to heart disease, fatty liver.
Multiple myeloma, also known as myeloma, is a type of bone marrow cancer. Multiple myeloma affects the plasma cells, blood cell, inside the bone marrow. Myeloma does not take the form of a … Continue Reading Study is first to link multiple myeloma protein to extramedullary disease.
It is known that one of the earliest sites of Alzheimer’s disease pathology is the hippocampus, a brain structure critical for the learning and memory processes that falter early in Alzheimer’s … Continue Reading Study shows how Alzheimer’s risk gene disrupts memory replay.
Proteins hold enormous promise to treat chronic conditions and irreversible injuries, for example, human growth hormone is encapsulated in tiny polymeric particles and used to treat children with stunted growth. … Continue Reading First ever system can control protein release from nanoparticles without encapsulation.
It is known that during disease, tau protein gets modified, changes its location in nerve cells and then aggregates. In healthy nerve cells, tau resides in a part of the … Continue Reading Previously unknown tau pathway leading to Alzheimer’s disease identified.
In Alzheimer’s, a build-up of plaque and dysfunctional proteins in the brain are known to be hallmarks of the disease. While the majority of Alzheimer’s research has focused on accumulation … Continue Reading New technique reveals that tau predicts Alzheimer’s disease progression.
Telomeres are critical for maintaining genomic integrity with telomere dysfunction or shortening commonly acquired during the process of tumour development. To add to this cancer cells require a mechanism to … Continue Reading Mystery solved as protein expressed in response to telomere shortening identified.