The growing worldwide epidemic of respiratory diseases can be attributed to simple everyday factors such as tobacco smoke, air pollution, occupational chemicals, or dust. These diseases involve the infection or … Continue Reading How airway cells work together in regeneration and aging.
Cystic fibrosis is a genetic-based disorder primarily affecting the lungs. The gene affected by cystic fibrosis is CFTR (cystic fibrosis transmembrane conductance regulator), controlling the movement of electrolytes in and … Continue Reading New lung cell type discovered.
Idiopathic pulmonary fibrosis is a potentially lethal disease associated with the presence of critically short telomeres, and currently lacking effective treatment. Now, a study from researchers at CNIO cures this … Continue Reading Researchers cure lung fibrosis in mice by lengthening telomeres.
Studying telomeres, the structures that protect the ends of chromosomes, has become a key issue in biology. In recent years, not only has their relation to aging been confirmed; defective … Continue Reading Extensive review maps all known diseases caused by defective telomeres.
Idiopathic pulmonary fibrosis (IPF) causes a gradual loss of respiratory capacity and can be lethal within a few years. The cause is unknown, although it can be attributed to a … Continue Reading Researchers identify the causal link between telomere shortening and idiopathic pulmonary fibrosis.
A landmark clinical study from researchers at the Toronto Western Hospital provides convincing evidence that a frequently overlooked therapy for genetically-caused emphysema is effective at slowing the progression of the … Continue Reading Landmark clinical trial validates efficacy of treatment for genetically caused emphysema.
A precision genetic analysis has yielded a surprising result, a network of neurons control breathing within the vagus nerve. Among these function-specific network of neurons, two types are dedicated to … Continue Reading Researchers identify neural networks within the vagus nerve responsible for breathing.
Lung diseases like emphysema and pulmonary fibrosis are common among people with malfunctioning telomeres, the ‘caps’ or ends of chromosomes. Now, researchers from Johns Hopkins University say they have discovered … Continue Reading Premature aging of stem cell telomeres, not inflammation, linked to emphysema.
By uncovering the mechanism by which fibrous tissue cells in the lung multiply, researchers at The Children’s Hospital Los Angeles (CHLA), Keck School of Medicine, Nanjing Drum Tower Hospital, Instituto Nacional de … Continue Reading Researchers map and control pulmonary fibrosis signalling pathway in preclinical trials.
A team led by UC San Francisco has discovered why mucus in the lungs of people with cystic fibrosis (CF) is thick, sticky and difficult to cough up, leaving these … Continue Reading Researchers identify the mechanism cystic fibrosis uses to thicken mucus in the lungs.
Mutation of one gene is all it takes to get cystic fibrosis (CF), but disease severity depends on many other genes and proteins. For the first time, researchers at the … Continue Reading Researchers map epigenetic pathways linked to cystic fibrosis disease severity.
Mutations in a gene that helps repair damaged chromosome ends may make smokers, especially female smokers, more susceptible to emphysema, according to results of a new study led by Johns … Continue Reading Epigenetic mutation which shortens telomeres linked to greater emphysema risk in smokers.