For several decades, addiction has come to be viewed as a disorder of the dopamine neurotransmitter system; however, this view has not led to new treatments. Numerous studies suggest that … Continue Reading Researchers identify specific neuron-type responsible for alcoholism.
Sigma receptors, particularly the sigma-1 receptor subtype, which are expressed in both neurons and glia of multiple regions within the central nervous system, are a unique class of intracellular proteins … Continue Reading Neuroprotective receptor found to have important role in support cells for the retina.
Synapses are specialized, protein-rich cell junctions that are essential for normal brain function and are dysfunctional in many diseases and disorders of the nervous system. Synapses are made up of … Continue Reading Study identifies elusive master regulator of synaptic protein sorting.
Prions are proteins in which the complex molecular three-dimensional folding process has simply gone astray. For reasons not yet understood, the misfolding nature of prions is associated to their ability … Continue Reading Study shows that the prion protein plays a role in depression.
Cancer researchers have known for years that tumours have unusual metabolisms, their rapid use of glucose is used as a diagnostic tool for tumours in PET scans. However, only recently … Continue Reading Study identifies new nutrient-based mechanism of cancer proliferation, drug resistance.
Since their discovery in the 1950s, transfer RNAs (tRNAs) have been best known for their role in helping the cell make proteins from messenger RNA templates. However, recent studies have … Continue Reading Researchers discover new species of tRNA responsible for sex-biased cancer proliferation.
Each year about one in every nine infants in the United States is born preterm (before 37 weeks), according to the Centers for Disease Control and Prevention. Premature birth can … Continue Reading Researchers identify molecular mechanisms within fetal lungs responsible for initiating labour.
Scientists have prior evidence that the hormone estrogen is a major driver in the growth of cervical cancer, however, a new study from the University of Wisconsin-Madison examining genetic profiles of … Continue Reading New study rewrites the role of estrogen in cervical cancer.
George Washington University (GW) researchers have found an important sex-dependent difference in the level of RORA protein in brain tissues of males and females. Specifically, females without autism have a … Continue Reading Another neurogenetic piece of the autistic sex-bias puzzle is found.
A chemical in the brain typically associated with cognition, movement and reward-motivation behaviour, among others, may also play a role in promoting chronic pain, according to new research from researchers … Continue Reading Researchers map dopamine based chronic-pain pathway in the spinal cord and brain.
In proof-of-concept experiments, researchers at University of California demonstrate the ability to tune medically relevant cell behaviours by manipulating a key hub in cell communication networks. The manipulation of this … Continue Reading How to reset a diseased cell.
Researchers at the University of North Carolina and the National Institutes of Health (NIH) have perfected a noninvasive ‘chemogenetic’ technique that allows them to switch off a specific behaviour in … Continue Reading New chemogenetic tool is the first to target different kinds of receptors on a neuron sequentially.
Researchers successfully implant and control light-sensitive opioid receptors in mice via optogenetics.
Despite the abuse potential of opioid drugs, they have long been the best option for patients suffering from severe pain. The drugs interact with receptors on brain cells to tamp … Continue Reading Researchers successfully implant and control light-sensitive opioid receptors in mice via optogenetics.
Researchers identify how the blood-brain barrier is maintained to control ‘tight junction’ function.
It has long been known that the brain is protected from alterations elsewhere in the body by a highly regulated gateway known as the blood-brain barrier, which allows only selected … Continue Reading Researchers identify how the blood-brain barrier is maintained to control ‘tight junction’ function.
A protein produced by nerve cells appears to be elevated in the blood of those with an aggressive form of neuroblastoma. The findings, presented at the American Association for Cancer … Continue Reading Human studies show specific nerve cell protein is elevated by an aggressive form of neuroblastoma.
In a new study from Saint Louis University, researchers discovered that drugs targeting the A3 adenosine receptor can turn off pain signals in the spinal cord to provide relief from … Continue Reading Researchers use A3 adenosine receptors to activate ‘off signals’ for chronic pain.