Nearly 12 million adults in the United States have been diagnosed with chronic obstructive pulmonary disease, with roughly 180,000 patients dying annually with end-stage refractory lung diseases. The only option … Continue Reading Donor stem cells used to grow fully functioning lungs in live mice.
Much work is being done on human limb regeneration concentrating on the specific microRNA circuit used by zebrafish, bichirs, and axolotls to regulate the regrowth of amputated extremities. Unfortunately, humans … Continue Reading Humans have the salamander-like ability to regenerate cartilage in joints.
Like a magician, the freshwater flatworm known as planaria can survive decapitation or even being cut into many pieces. Its ability to fully regenerate from tiny remnants of tissue is … Continue Reading Elusive key molecular signal for planarian stem cell regeneration identified.
Heart failure is one of the main health problems worldwide, and the urgent medical needs relating to it have positioned cardiovascular research as one of the most actively evolving fields … Continue Reading Study links adult heart regeneration to telomere length in animal model.
More than 600,000 patients in the United States alone suffer from end-stage liver disease, or cirrhosis. The only available cure is liver transplantation, but the shortage of donor livers means … Continue Reading New approach repairs living liver from within with no need of cell transplants.
Damage to axons in the central nervous system (CNS) typically results in permanent damage and severed axons in the adult mammalian CNS do not spontaneously regenerate to restore lost functions. … Continue Reading Researchers regenerate damaged nerves via the eye using optogenetics.
It is known that the age-related growth differentiation factor 11 (GDF11) is member of the transforming growth factor β superfamily of proteins. Circulating GDF11 concentrations appear to decline with age, … Continue Reading Study identifies previously unknown molecular pathway in aging.
It is known that the regenerative capacity of the injured central nervous system (CNS) in adult mammals is severely limited, yet axons in the peripheral nervous system (PNS) regrow, albeit … Continue Reading Gene pathway responsible for peripheral nervous system regeneration identified.
The peripheral nervous system is a vast network of nerves that exists primarily outside of brain and spinal cord and connects to the far reaches of the body. The very … Continue Reading Study shows how protein promotes regeneration of injured peripheral nerves.
In humans, up to half of body mass is made up of skeletal muscle, which plays a key role in locomotion, posture, and breathing. Although skeletal muscles can overcome minor … Continue Reading Biologic-free mechanically induced muscle regeneration successful in animal studies.
In the field of iPS cell-based regenerative medicine, advanced research with clinical applications for many organs and tissues, such as the retina, has steadily progressed. However, growing a kidney from … Continue Reading Human stem cell-derived kidneys connect to blood vessels when transplanted into mice.
Researchers at the Lankenau Institute for Medical Research (LIMR), University of California and Allergan have used a primordial form of energy produced in mammals to achieve spontaneous tissue regeneration in mice, … Continue Reading Researchers achieve spontaneous tissue regeneration in mice.
Using proteomics techniques to study injured optic nerves, researchers at Boston Children’s Hospital have identified previously unrecognized proteins and pathways involved in nerve regeneration. The new study showed that adding … Continue Reading Researchers see an unprecedented degree of nerve regeneration using proteomics.