The female uterus is essential for reproduction in all mammals, meaning any trauma or disease affecting this organ detrimentally could compromise a woman’s ability to conceive or carry a viable … Continue Reading A tissue-engineered uterus supports live births in rabbits.
Nearly 12 million adults in the United States have been diagnosed with chronic obstructive pulmonary disease, with roughly 180,000 patients dying annually with end-stage refractory lung diseases. The only option … Continue Reading Donor stem cells used to grow fully functioning lungs in live mice.
Much work is being done on human limb regeneration concentrating on the specific microRNA circuit used by zebrafish, bichirs, and axolotls to regulate the regrowth of amputated extremities. Unfortunately, humans … Continue Reading Humans have the salamander-like ability to regenerate cartilage in joints.
There are a staggering estimated 785,000 new heart attack cases in the United States each year, with no gold standard treatment for repairing the resulting damage to cardiac tissue. There … Continue Reading First-in-human trial shows hydrogel to repair heart is safe to inject.
Blood vessels are the parts of the circulatory system responsible for transporting oxygen-rich red blood cells, nutrients, and immune cells throughout the body, with defects in these transport systems shown … Continue Reading Researchers identify elusive stem cells capale of producing fully-functional blood vessels.
Type I diabetes is a disease with two parts, firstly, the beta cells are killed by the body’s own immune system, and then secondly they fail to regenerate, causing the … Continue Reading Previously unknown type of regenerating insulin-producing cell discovered.
The limited removal of metabolic waste products in dialyzed kidney patients leads to high morbidity and mortality. A bioartificial kidney could replace the need for dialysis or transplantation in the … Continue Reading Researchers develop functional living membrane in massive leap towards a bioartificial kidney.
Lung disease causes more than 200,000 deaths annually in the United States. Although the lung is generally considered slow to respond to disease and injury, it does undergo regenerative processes, … Continue Reading Researchers develop tissue-engineered model of human lung and trachea.
It is known that nerves in the central nervous system of adult mammals do not usually regenerate when injured. However, the granule cell, a nerve cell located in the cerebellum, … Continue Reading Key molecule in the elusive regeneration of cerebellum synaptic connections identified.
Like a magician, the freshwater flatworm known as planaria can survive decapitation or even being cut into many pieces. Its ability to fully regenerate from tiny remnants of tissue is … Continue Reading Elusive key molecular signal for planarian stem cell regeneration identified.
It is known that skeletal muscle regeneration is impaired in age-related diseases such as sarcopenia, which is marked by reduced muscle regenerative capacity with aging, due in part to a … Continue Reading Study identifies gene responsible for regeneration of injured muscle by adult stem cells.
One of the processes associated with aging is progressive shortening of telomeres, DNA-protecting structures at the ends of chromosomes, like the plastic tips on shoelaces. Each time a cell divides, … Continue Reading Male hormone reverses cell aging, increases telomere length, in clinical trial.
During exercise, muscle function needs to significantly increase; this requires that the uptake and breakdown of the two main nutrients of myofibers, glucose and fatty acids (FAs), markedly rise. The … Continue Reading First ever bone-derived hormone to affect exercise capacity identified.
Nervous system injuries affect over 90,000 people every year, with spinal cord injuries alone estimated to affect 10,000 people each year. As a result of this high incidence of neurological … Continue Reading Researchers successfully control mitochondria to regenerate damaged neurons.
Heart failure is one of the main health problems worldwide, and the urgent medical needs relating to it have positioned cardiovascular research as one of the most actively evolving fields … Continue Reading Study links adult heart regeneration to telomere length in animal model.
More than 600,000 patients in the United States alone suffer from end-stage liver disease, or cirrhosis. The only available cure is liver transplantation, but the shortage of donor livers means … Continue Reading New approach repairs living liver from within with no need of cell transplants.