In biology, cells sense and process many environmental inputs. These inputs are then processed to produce outputs, such as development, differentiation, or immune responses modulated via the regulation of specific … Continue Reading CRISPR used to develop first biosynthetic dual-core cell computer.
The microbiota is a diverse bacterial microorganism living in and on all mammals whose metabolic product provides balance, immunity and, in some cases, disease to the host’s body. Therefore, it … Continue Reading Microbiome activity revealed in unprecedented detail by tRNA sequencing.
The origins of life on earth have been a fascination for researchers and the public alike for many years. To date, researchers have traced the arc of life back several … Continue Reading Synthetic microorganisms allow researchers to study billion-year-old evolutionary mysteries.
It is known that skeletal muscle regeneration is impaired in age-related diseases such as sarcopenia, which is marked by reduced muscle regenerative capacity with aging, due in part to a … Continue Reading Study identifies gene responsible for regeneration of injured muscle by adult stem cells.
People with diabetes have a two to five time higher risk of developing cardiovascular diseases. For decades physicians have noticed unhealthy changes in the hearts of diabetics called diabetic cardiomyopathy, … Continue Reading Study identifies RNA-based mechanism underlying how diabetes damages the heart.
The earliest events that occur following mucosal HIV-1 exposure remain poorly understood, largely because the eclipse period of infection prior to the detectable disease is very difficult to study in … Continue Reading Earliest ever events following HIV infection mapped for the first time.
Coeliac disease is a chronic, immunological disease that is manifested as intolerance to gluten proteins present in wheat, rye and barley. This intolerance leads to an inflammatory reaction in the … Continue Reading Gene crucial to the development of celiac disease found in ‘junk’ DNA.
Unprecedented precision study identifies the four genes responsible for blood stem cell development.
Every day, over 100 billion new mature blood cells are generated in an adult human. This major production places high demands on the blood stem cells which must be capable … Continue Reading Unprecedented precision study identifies the four genes responsible for blood stem cell development.
The nucleolus is a crucial membrane-less structure or organelle that takes up about 25% of the nucleus of a mammalian cell. The largest membrane-less organelle, the nucleolus has been compared … Continue Reading Protein ‘glue’ which holds biomolecules within the nucleolus, identified.
It is known that the regenerative capacity of the injured central nervous system (CNS) in adult mammals is severely limited, yet axons in the peripheral nervous system (PNS) regrow, albeit … Continue Reading Gene pathway responsible for peripheral nervous system regeneration identified.
Heart muscle is activated by ionized calcium, with the signaling pathway utilising allosteric mechanisms in the thin filament. Knowledge about the structure-function relationship among proteins in this filament is critical … Continue Reading Previously unknown protein critical to heart muscle contraction identified.
Epigenetics is a process whereby environmental factors can affect DNA and the mechanism by which DNA is transcribed and translated into proteins. Epigenetic regulation has been observed to affect a … Continue Reading Researchers reprogram social behaviour in carpenter ants using epigenetic drugs.
A fundamental law of genetics states that progenies do not inherit epigenetically-based adaptive, pathological or neural features acquired in response to environmental conditions. However, recent studies seem to contradict this … Continue Reading Researchers map ‘epigenetic inheritability’ in fathers sperm caused by diet.
How HIV-1 overcomes the person’s defenses and infects their cells has been studied intensively for over 30 years. While much has been learned, there remain events in the viral life … Continue Reading Researchers reveal and image new phase of HIV infection for the first time.
The use of blood-based liquid biopsies to detect, diagnose, and monitor cancer may enable earlier diagnosis of cancer, lower costs by tailoring molecular targeted treatments, improve convenience for cancer patients, … Continue Reading New blood test can detect, classify and pinpoint cancer location from one drop of blood.
The serotonin receptors, also known as 5-hydroxytryptamine receptors or 5-HT receptors, are a group of G protein-coupled receptors and ligand-gated ion channels found in the central and peripheral nervous systems. … Continue Reading Researchers identify previously unknown subtypes of 5HT neurons.