The unique properties of naturally occurring immune cells in the human body have inspired many efforts to synthetically engineer a unit capable of mimicking their behaviors. Now, a study from … Continue Reading Researchers develop synthetic T cells, that function like the human version.
When the body is fighting an invading pathogen, white blood cells, including T cells, must respond. T-cell receptors (TCRs) recognize pathogens during T-cell–mediated adaptive immune responses. The binding between TCRs … Continue Reading New imaging provides unprecedented detail of immune cells’ surface.
HIV, is a virus that attacks the body’s immune system. If left untreated, HIV can progress and develop into AIDS. HIV infection is enhanced by adhesive structures that form between … Continue Reading First-ever study captures HIV cell-to-cell transmission in a living animal.
T cells are the immune cells responsible for recognizing and destroying specific invaders, such as viruses, bacteria, or cancer. Their activity is highly tunable, with signals from other cells adjusting … Continue Reading Study identifies a new regulator of immune responses.
The body has an army of millions of immune cells. These cells contain receptors generated through random genetic rearrangements, a clever strategy to keep them ready to fight unfamiliar viruses … Continue Reading Previously unknown immune cell identified, with implications for T1 diabetes.
Type 1 diabetes is the autoimmune form of diabetes, in which insulin-producing beta cells in the pancreas are destroyed by immune cells, especially those known as T cells. Insulin is … Continue Reading Researchers identify previously unknown class of antigen present in T1 diabetes.
An estimated 100,000 Canadians live with multiple sclerosis; there is currently no cure for the disease. Modern scientific understanding has considered multiple sclerosis (MS) to be a disease controlled by the … Continue Reading Specific subset of b-cell responsible for Multiple Sclerosis disease activity identified.
The intriguing relationship between metabolism and the immune system has been receiving increasing attention over the past few years. It is known that macrophages accumulate in adipose tissue during obesity. … Continue Reading Researchers identify immune cells that fight obesity in animal model.
B lymphocytes, also known as B cells, are the only cells to produce antibodies, which the immune system needs to fight off foreign intruders like pathogens in order to protect … Continue Reading Researchers identify previously unknown protein in immune cells.
Antigen receptor genes are assembled by controlled, large-scale deletions and inversions. Errors in this process, known as V(D)J recombination, produce aberrant genomic rearrangements, which can fuel the development of T- … Continue Reading Researchers identify points where incorrect immune cell DNA editing causes blood cancer.
To be activated, T cells must first recognize an antigen, receive appropriate costimulatory signals, and then encounter inflammatory cytokines to expand the immune response. This immune response has been harnessed … Continue Reading New T-cell regulation discovery set to rewrite immunology text books.
Autoimmune uveitis, which accounts for up to 15% of severe visual handicap in the Western world, affects the working-age population and significantly affects public health. Patients often have detectable immune … Continue Reading Study reveals how T-cells traverse blood-retinal barrier in eye disease.
The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety … Continue Reading In world’s first, immune cells imaged responding to infection at the same time.
A collaborative team from The University of Texas and the National Institutes of Health have developed an inhalable vaccine that successfully protects primates against Ebola in simian trials. The team … Continue Reading First ever inhalable ebola vaccine is successful in simian trials.
An analysis of five families has revealed a previously unknown genetic immunodeficiency, says an international team led by researchers from Boston Children’s Hospital. The condition, linked to mutations in a … Continue Reading International team discovers previously unknown genetic immunodeficiency.
New ‘can-opener’ molecule forces HIV virus open to expose vulnerable regions for antibodies to kill.
The human immunodeficiency virus (HIV) is often likened to a hermetically sealed tin can no one has yet been able to break open. Now, researchers at the University of Montreal … Continue Reading New ‘can-opener’ molecule forces HIV virus open to expose vulnerable regions for antibodies to kill.