Recent efforts to develop a treatment for Alzheimer’s disease and other dementias have focused heavily on removing toxic tau proteins from the brain. The tau protein is known to bind … Continue Reading Study shows that structure of toxic tau aggregates determines type of dementia, and rate of progression.
Alzheimer’s disease is a neurodegenerative disorder characterized by progressive memory loss and cognitive dysfunction. It affects more than 30 million people worldwide, including an estimated 5.4 million Americans. One in … Continue Reading Dysfunction in neuronal transport mechanism linked to Alzheimer’s disease.
For decades, scientists have known that people with two copies of a gene called apolipoprotein E4, or ApoE4, are much more likely to have Alzheimer’s disease at age 65 than … Continue Reading Study shows why people with the ApoE4 gene are more susceptible to Alzheimer’s disease.
It is known that during disease, tau protein gets modified, changes its location in nerve cells and then aggregates. In healthy nerve cells, tau resides in a part of the … Continue Reading Previously unknown tau pathway leading to Alzheimer’s disease identified.
In Alzheimer’s, a build-up of plaque and dysfunctional proteins in the brain are known to be hallmarks of the disease. While the majority of Alzheimer’s research has focused on accumulation … Continue Reading New technique reveals that tau predicts Alzheimer’s disease progression.
Tauopathies are neurodegenerative diseases that are signified by the presence of irregular tangle-like clumps of the protein tau that appear in the brain and accumulate during as the disease progresses. … Continue Reading Study identifies a previously unknown mechanism of neurofibrillary tangle formation.
Examining post-mortem tissue from the brains of people with Alzheimer’s disease, Stanford University researchers state they have identified what appear to be iron-containing microglia, specialized scavenger cells that sometimes become … Continue Reading A human study identifies region specific iron-containing microglia in Alzheimer’s brains.
Through studying brain scans and cerebrospinal fluid of healthy adults researchers at Washington University have shown that changes in key biomarkers of Alzheimer’s disease during midlife can help identify those who … Continue Reading First ever large-scale human study validates multiple biomarkers for Alzheimer’s disease.
Alzheimer’s disease is the most common form of dementia, affecting over 44 million people worldwide. Inside the brain, Alzheimer’s disease is characterized by loss of neurons, and presence of abnormal … Continue Reading Protein involved in Alzheimer’s proven to have a role in weakening synaptic plasticity.
Degeneration of the white matter of the brain may be an early marker of specific types of Alzheimer’s disease (AD), including early-onset AD, according to results of a new study … Continue Reading Researchers identify specific types of Alzheimer’s disease using white matter neuroimaging test.
A new UCLA study takes another step toward the early understanding of a degenerative brain condition called chronic traumatic encephalopathy, or CTE, which affects athletes in contact sports who are … Continue Reading Neuroimaging study identifies characteristic pattern of protein deposits in brains of retired athletes who suffered concussions.
After six years of painstaking research, a UCLA-led team has validated the first standardized protocol for measuring one of the earliest signs of Alzheimer’s disease, the atrophy of the part … Continue Reading Harmonized neuroimaging protocol for measuring early sign of Alzheimer’s has been developed.
A unique class of proteins in the human body has the ability to alter their configuration. These so-named intrinsically disordered proteins (IDPs) lack a fixed or ordered three-dimensional structure, which … Continue Reading Researchers investigate how form affects function and aggregation of tau protein in the brain.
Drugs that boost the function of a specific type of neurotransmitter receptor may provide benefit to patients with the second most common type of dementia, according to research by scientists … Continue Reading Scientists boost receptor-function to treat Frontotemporal dementia.