Idiopathic pulmonary fibrosis is a potentially lethal disease associated with the presence of critically short telomeres, and currently lacking effective treatment. Now, a study from researchers at CNIO cures this … Continue Reading Researchers cure lung fibrosis in mice by lengthening telomeres.
Telomeres are our own personal inbuilt clock found at the end of chromosomes dictating how and when we age, with these protective caps ensuring no damage comes to the DNA … Continue Reading Researchers identify previously unknown telomere-specific protein.
One of the processes associated with aging is progressive shortening of telomeres, DNA-protecting structures at the ends of chromosomes, like the plastic tips on shoelaces. Each time a cell divides, … Continue Reading Male hormone reverses cell aging, increases telomere length, in clinical trial.
Telomere dysfunction has been proposed as a key event that causes cancer progression. According to this model, progressive telomere shortening results in telomere dysfunction and end-to-end chromosomal fusions. The resulting … Continue Reading Researchers identify telomere-based mechanism which turns mutant cells into aggressive cancers.
Heart failure is one of the main health problems worldwide, and the urgent medical needs relating to it have positioned cardiovascular research as one of the most actively evolving fields … Continue Reading Study links adult heart regeneration to telomere length in animal model.
Telomeres are critical for maintaining genomic integrity with telomere dysfunction or shortening commonly acquired during the process of tumour development. To add to this cancer cells require a mechanism to … Continue Reading Mystery solved as protein expressed in response to telomere shortening identified.
An enzyme called telomerase plays a significant role in aging and most cancers. Telomerase’s primary job is to maintain the DNA in telomeres, the structures at the ends of a … Continue Reading Study provides previously unseen structure of telomere-controlling enzyme.
In human cells, shortened telomeres, the protective caps at the ends of chromosomes, are both a sign of aging and contribute to it. The effects of chronic diseases such as … Continue Reading Researchers use dietary supplement in atherosclerotic mice to lengthen telomeres.
Studying telomeres, the structures that protect the ends of chromosomes, has become a key issue in biology. In recent years, not only has their relation to aging been confirmed; defective … Continue Reading Extensive review maps all known diseases caused by defective telomeres.
Scientists from the Spanish National Cancer Research Centre (CNIO) have discovered a new strategy to fight cancer, which is very different from those described to date. Their work shows for … Continue Reading Researchers have successfully ‘uncapped’ telomeres in animal lung cancer model.
In results presented at the American Association for Cancer Research (AACR) Annual Meeting 2015, a collaborative study by the University of Colorado and the National Cancer Institute (NCI) reports that … Continue Reading Precision medicine study shows the most frequently altered gene in bladder cancer.
Mutations in a gene that helps repair damaged chromosome ends may make smokers, especially female smokers, more susceptible to emphysema, according to results of a new study led by Johns … Continue Reading Epigenetic mutation which shortens telomeres linked to greater emphysema risk in smokers.