Cancer is a genetic disease, caused by specific changes to the genes controlling the way cells function, particularly how they grow and divide. Genes are functional units of heredity made … Continue Reading Ancient DNA could identify and kill cancer.
Epigenetic dysfunction is implicated in many neurological and psychiatric diseases, including Alzheimer’s disease and schizophrenia. Consequently, histone deacetylases (HDACs) are being aggressively pursued as therapeutic targets. However, a fundamental knowledge … Continue Reading Researchers image the epigenetics of the human brain for the first time ever.
In the brain, patterns of neural activity are perfectly balanced. The interplay between activating and inhibitory neurotransmitters ensures that the level of activity stays within the physiological range. Neuronal degeneration … Continue Reading Researchers begin to map neuroprotective pathway after epileptic seizure.
It has long been known that transcriptional regulation during embryonic development relies on the regulation of thousands of genes. Within a particular cell type defined sets of DNA-binding transcription factors … Continue Reading Researchers map how transcription factors interact to create a heart.
The human nervous system is made up of an astonishing diversity of neurons. And yet only a very small number of proteins are needed to generate and determine the identity … Continue Reading Researchers identify a previously unknown regulatory mechanism of neurogenesis.
Alzheimer’s disease poses a health problem of pandemic proportions. It is estimated that by the year 2030 there will be greater than 60 million people worldwide with AD, and $375 … Continue Reading Newly identified role for ApoE explains its effects in Alzheimer’s.
Epigenetics is a process whereby environmental factors can affect DNA and the mechanism by which DNA is transcribed and translated into proteins. Epigenetic regulation has been observed to affect a … Continue Reading Researchers reprogram social behaviour in carpenter ants using epigenetic drugs.
Growing insights about a significant part of the genome, the dark matter of DNA, have fundamentally changed the way scientists approach the study of diseases. The human genome contains about … Continue Reading Study provides first ever comprehensive profile of lncRNAs in human cancers.
While research has traditionally focused on finding individual genes responsible for Autism Spectrum Disorders (ASD), recent research has found links between epigenetic regulation and ASD in human patients. Epigenetics is … Continue Reading Study identifies epigenetic regulators linked to autism-like syndrome.
The heart is arguably the hardest working muscle in the human body and without its incessant, regular beating the body’s organs would be starved of life-giving nutrients. Yet how the … Continue Reading Researchers identify precision medicine for the development of healthy heart muscle.
DNA methylation is essential for the proper control of gene expression and cell identity, what enables cells with the same genetic material to become, for example, a nerve cell, a … Continue Reading Single-cell imaging developed which can record DNA methylation in real time.
After it is transcribed from DNA, RNA can go on to many fates. While the most familiar path may lead directly to the production of protein, RNA molecules themselves can … Continue Reading Researchers unlock another piece of the RNA sequencing puzzle.
As humans grow older, they lose strength and muscle mass. Skeletal muscle weakness and atrophy are among the most pervasive and disruptive effects of aging. In nearly all people, even … Continue Reading Researchers identify precise cause of muscle weakness and loss due to aging.
The immune system not only responds to infections and other potentially problematic abnormalities in the body, it also contains a built-in brake in the form of regulatory T cells. These … Continue Reading Researchers identify a previously unknown regulator of the immune system.
Another step forward has just been taken in the area of synthetic biology. Research teams from Inserm, CNRS (French National Centre for Scientific Research), Montpellier Regional University Hospital and Stanford … Continue Reading Intelligent bacteria, bactodetectors, have been programmed to successfully detect disease.
When cells are normal and unstressed, the molecule keeps transcription moving so that genes are ‘expressed’ and RNA is jotted down more quickly. When cells are stressed and transcription runs … Continue Reading Researchers identify key molecule which halts transcription of cell’s genetic code.