The body has an army of millions of immune cells. These cells contain receptors generated through random genetic rearrangements, a clever strategy to keep them ready to fight unfamiliar viruses … Continue Reading Previously unknown immune cell identified, with implications for T1 diabetes.
The autonomic nervous system, made up of sympathetic and parasympathetic branches, is known to regulate blood glucose levels by directly controlling insulin secretion by the pancreas. Insulin secretion and blood … Continue Reading Hormone inhibits neuronal connections between the brain and pancreas in neurodevelopment.
It is known that the loss or dysfunction of islet β cells in the pancreas results in an imbalance in blood glucose homeostasis, leading to the development of type 2 … Continue Reading Researchers identify new links between nicotine and type 2 diabetes.
Brown adipose tissue, brown fat, is a key tissue that controls the energy balance of whole body. Excessive energy is dissipated in the form of heat by brown adipocytes specialized … Continue Reading Study identifies pathway in brown fat responsible for better metabolism.
A large body of data gathered over the last decades has identified the neuronal pathways which link the central nervous system with the autonomic innervation of the endocrine pancreas. These … Continue Reading Study shows brain cell mitochondria controls blood-sugar levels after a meal.
Type 1 diabetes is the autoimmune form of diabetes, in which insulin-producing beta cells in the pancreas are destroyed by immune cells, especially those known as T cells. Insulin is … Continue Reading Researchers identify previously unknown class of antigen present in T1 diabetes.
Type 2 diabetes is a chronic illness characterised by the presence of elevated blood glucose levels. It accounts for between 80 and 90% of diabetes cases and is one of … Continue Reading Large-scale study identifies an epigenetic marker for Type 2 diabetes.
Obesity is associated with the risk of developing type-2 diabetes, nonalcoholic fatty liver disease, cardiovascular disease and cancer. However, it has been increasingly recognized that obesity is not a homogeneous … Continue Reading New test can warn patients years before onset of diabetes.
All mammals, including humans, have two types of fat with completely opposite functions. These are white fat, which stores energy and is linked with diabetes and obesity; and brown fat, … Continue Reading Researchers identify epigenetic switch which generates calorie-burning brown fat.
A primary function of cytokines is to initiate immune responses; however, it has become increasingly apparent that they play major roles in the regulation of energy homeostasis, implicating them in … Continue Reading Sensor protein shown to have dual role in immune-system and metabolism.
Ten million Canadians are living with diabetes or pre-diabetes. The Canadian Diabetes Association reports that more than 20 Canadians are newly diagnosed with the disease every hour of every day. … Continue Reading New mitochondria-based insulin amplifier pathway identified in T2 diabetes.
High blood sugar is a defining characteristic of Type 2 diabetes and the cause of many of the condition’s complications, including kidney failure, heart disease, and blindness. Most diabetes medications … Continue Reading Researchers block mitochondrial glucose production to treat type 2 diabetes in preclinical trials.
To combat pathogens, the immune system has developed various mechanisms to detect, defend against and even destroy micro-organisms that are harmful to the body. This includes antimicrobial peptides and natural … Continue Reading International team identifies bacteria which protect against type 1 diabetes.
It’s been known that in the presence of obesity, the endoplasmic reticulum (ER) dysfunction is unable to perform one of its key functions: initiating a cascade of intracellular events called … Continue Reading New obesity-related mechanism identified in the development of Type 2 diabetes.
Type 1 diabetes is an autoimmune disease, which primarily surfaces in childhood, where the immune system attacks the insulin-producing cells of the pancreas, leaving children facing a lifetime of daily … Continue Reading Lower levels of four proteins crucial for immune response found in T1 diabetes patients.
It is well-known that insulin resistance is common in people who are obese, pre-diabetic or have Type 2 diabetes. The fact that obesity increases the risk of cardiovascular disease and … Continue Reading Researchers image the effect of insulin resistance in the brain, link to Alzheimer’s disease.