The earliest events that occur following mucosal HIV-1 exposure remain poorly understood, largely because the eclipse period of infection prior to the detectable disease is very difficult to study in … Continue Reading Earliest ever events following HIV infection mapped for the first time.
Brazil is in the midst of an unprecedented epidemic of Zika virus (ZIKV), a flavivirus that is transmitted by mosquitoes and sexually, which was first detected in the country in … Continue Reading New research provides mechanism and evidence of how Zika virus causes microcephaly in newborns.
It is known that HIV, the causative agent of AIDS, is severely species restricted, and, to date, only humans and chimpanzees have been shown to be susceptible to infection. Human … Continue Reading First-ever study proves HIV targets & replicates in human macrophages.
Envelope glycoprotein GP120 is a glycoprotein exposed on the surface of the HIV envelope (ENV). The envelope glycoprotein trimer is essential for HIV entry into cells as it plays a … Continue Reading New breakthrough imaging shows HIV structure in unprecedented detail.
Ebola virus disease (EVD) is a severe infectious disease which caused an epidemic in West Africa in 2013-2015, and has resulted in at least 10,000 confirmed deaths. Early diagnosis of … Continue Reading Cell-free microRNA identified as biomarker for early diagnosis of Ebola.
In recent years, Ebola outbreaks have increased in frequency, duration, and geographical spread, underscoring the need for pre- and post-exposure treatments. Antibodies targeting the Ebola virus surface glycoprotein, the viral structure … Continue Reading Previously unknown ebola-fighting antibodies identified in outbreak survivor’s blood.
When pathogens infect the cells of the body, the infection sets off a chain reaction involving the immune system that changes the expression of hundreds of genes. Gene expression is … Continue Reading Multiple signatures left on the immune system by viral infections identified for the first time.
How HIV-1 overcomes the person’s defenses and infects their cells has been studied intensively for over 30 years. While much has been learned, there remain events in the viral life … Continue Reading Researchers reveal and image new phase of HIV infection for the first time.
Another year of growth for the Healthinnovations, many great breakthroughs, with previously immature technologies and disciplines coming into their own, as crucial parts of global innovation. For instance, biomarkers have … Continue Reading The Top Ten Healthinnovations of 2015.
Herpes simplex virus (HSV) is found in the brain cells of approximately 90% of the world’s population and leads to cold sores, recurrent eye infections, genital lesions, and in rare … Continue Reading Study shows how the herpes simplex virus reactivates in neurons.
Bacteriophages are abundant in the environment, which means they are ecologically friendly. They infect and kill only bacteria, which means they could be used as novel biocontrol agents and even … Continue Reading Bacteriophage decontaminates infant formula infected with superbug.
MERS is caused by an emerging human coronavirus, which is distinct from the SARS coronavirus. Since its identification in 2012, MERS has been linked to over 1,300 infections and close … Continue Reading New synthetic-DNA vaccine protects against MERS in simian model.
The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety … Continue Reading In world’s first, immune cells imaged responding to infection at the same time.
A collaborative team from The University of Texas and the National Institutes of Health have developed an inhalable vaccine that successfully protects primates against Ebola in simian trials. The team … Continue Reading First ever inhalable ebola vaccine is successful in simian trials.
Infectious diseases such as hepatitis C and some of the world’s deadliest superbugs, C. difficile and MRSA among them, could soon be detected much earlier by a unique diagnostic test, … Continue Reading Researchers develop world’s most sensitive universal diagnostic test for all disease.
A research team from Duke-NUS, Vanderbilt University, the University of North Carolina and the University of California, Berkeley has found the second-to-last piece of the puzzle needed to potentially cure or … Continue Reading Researchers identify the elusive antibody that zaps resilient dengue serotype 2.