Heart muscle is activated by ionized calcium, with the signaling pathway utilising allosteric mechanisms in the thin filament. Knowledge about the structure-function relationship among proteins in this filament is critical in understanding the physiology and pathology of the cardiac function and disease; however it remains obscure.  Now, researchers at UT Southwestern have identified a previously unknown protein, which they have named DWORF, in human heart cells … Continue reading Previously unknown protein critical to heart muscle contraction identified.