Dopamine deficiency in the basal ganglia is known to cause severe motor dysfunctions such as slowness of movement, or bradykinesia, as seen in Parkinson’s disease. Dopamine binds D1 and D2 receptors that are expressed in the nerve cells of the striatum, a structure of the basal ganglia, and exerts different effects on the nerve cells. However, how dopamine controls these receptors, the information flow in the … Continue reading Study identifies the cause of slowness of movement in Parkinson’s disease.