It has long been known that transcriptional regulation during embryonic development relies on the regulation of thousands of genes. Within a particular cell type defined sets of DNA-binding transcription factors (TFs), proteins that direct gene expression, functioning on defined genomic elements are involved in determining cellular identity.  Combinatorial interactions of small numbers of TFs have been proposed to underlie tissue-specific gene expression in mammalian organogenesis. … Continue reading Researchers map how transcription factors interact to create a heart.