The first-ever systematic study of the genomes of patients with ALK-negative anaplastic large cell lymphoma (ALCL), a particularly aggressive form of non-Hodgkin’s lymphoma, shows that many cases of the disease are driven by alterations in the JAK/STAT3 cell signaling pathway. The new study from Columbia University Medical Center (CUMC) and Weill Cornell Medical College also demonstrates, in mice implanted with human-derived ALCL tumours, that the … Continue reading Researchers demystify rare, deadly lymphoma.