Skip to content

Augmented bacteriophage modulates gut microbiota to fight cancer.

a study from researchers at Wuhan University develops a hybrid bacteriophage or phage capable of modulating the gut microbiota to suppress colorectal cancer growth. The team states they selected the M13 phage species due to its propensity for binding to Fn, coating the phage in silver to successfully block immunosuppression in the tumor microenvironment (TME).

Symbiotic bacteria can be found living in and on the majority of our body’s surfaces, with 99 percent of these micro-interlopers inhabiting the human gastrointestinal tract. These intestinal microbes are referred to as the gut microbiota, and are crucial in the regulation of the immune system, as well as aiding in the development of cancer.

Specifically, evidence suggests the gut microbiota is instrumental in the production of colorectal cancer tumors, aided by the bacterium Fusobacterium nucleatum (Fn). The Fn microbial species is thought to increase the level of a type of immune cell known as a myeloid cell, implicated in the suppression of other white blood cells, to hamper the host’s anticancer immune response.

Augmented phage fights cancer

Now, a study from researchers at Wuhan University develops a hybrid bacteriophage or phage capable of modulating the gut microbiota to suppress colorectal cancer growth. The team states they selected the M13 phage species due to its propensity for binding to Fn, coating the phage in silver to successfully block immunosuppression in the tumor microenvironment (TME). The opensource study is published in the journal of Science Advances.

Previous studies show symbionts contained within our gastrointestinal system have profound antitumor effects whilst modulating the host immune system. In contrast, this gut bacteria can also promote tumor growth, as well as inhibiting cancer treatment, with this precipitously balanced microbial community proving vulnerable even to antibiotic treatment.

Recent studies have linked the development of colorectal cancer development to the gut microbiota, particularly where the presence of Fn is detected in cancerous colorectal tissue. It is thought this individual species of bacteria recruits more myeloid cells into diseased tissue resulting in an immune-suppressed TME, further dampening T cell response.

This information taken together points to a naturally-based treatment able to manipulate specific gut bacteria to boost antitumor effects. The current study augments a species of bacteriophage, a naturally-occurring virus possessing the ability to target and kill specific bacteria, assisted by nanomaterials to boost its antitumor effects.

Suppressing cancer via the gut

The current study utilizes a bacteriophage display library to identify a species capable of binding Fn bacteria, called the M13 phage. Silver nanoparticles were then assembled electrostatically on the surface of the M13 phage’s capsid protein to achieve specific clearance of Fn and remodel the TME.

Results show once the hybrid M13 phages accumulated in the TME they selectively killed protumor Fn and blocked the recruitment of immunosuppressant myeloid cells. Data findings show in mice, the hybrid phages also target Fn in the gut all the while reducing myeloid cell migration to the tumor site.

The lab states, in addition, their augmented bacteriophage promotes the activation of antigen-presenting cells to boost the immune system for colorectal cancer suppression. They go on to add it was demonstrated the hybrid phage boosted the host immune response, delayed the progression of colorectal cancer, and prolonged the survival of mice. They stress if there is no specific colonization of Fn in the tumor it is unlikely this pseudo-natural cancer therapy will work.

Treat the TME via the gut

The team surmises they develop a new type of immunotherapy targeting colorectal cancer, capable of regulating the gut microbiota to reverse immunosuppressive TME through the augmentation of phages. For the future, the researchers state their work hints at the possibility of selectively modulating individual microbiota species using phages also capable of boosting immunity to dampen the progression of colorectal cancer.

Source: Wuhan University

Don’t miss the latest discoveries from the health innovator community:

 

Healthinnovations View All

Michelle Petersen is the founder of Healthinnovations, having worked in the health and science industry for over 21 years, which includes tenure within the NHS and Oxford University. Healthinnovations is a publication that has reported on, influenced, and researched current and future innovations in health for the past decade.

Michelle has been picked up as an expert writer for Informa publisher’s Clinical Trials community, as well as being listed as a blog source by the world’s leading medical journals, including the acclaimed Nature-Springer journal series.

Healthinnovations is currently indexed by the trusted Altmetric and PlumX metrics systems, respectively, as a blog source for published research globally. Healthinnovations is also featured in the world-renowned BioPortfolio, BioPortfolio.com, the life science, pharmaceutical and healthcare portal.

Most recently the Texas A&M University covered The Top 10 Healthinnovations series on their site with distinguished Professor Stephen Maren calling the inclusion of himself and his team on the list a reflection of “the hard work and dedication of my students and trainees”.

Michelle Petersen’s copy was used in the highly successful marketing campaign for the mega-hit film ‘Jumanji: The Next Level, starring Jack Black, Karen Gilian, Kevin Hart and Dwayne ‘The Rock’ Johnson. Michelle Petersen’s copywriting was part of the film’s coverage by the Republic TV network. Republic TV is the most-watched English language TV channel in India since its inception in 2017.

An avid campaigner in the fight against child sex abuse and trafficking, Michelle is a passionate humanist striving for a better quality of life for all humans by helping to provide traction for new technologies and techniques within healthcare.

One thought on “Augmented bacteriophage modulates gut microbiota to fight cancer. Leave a comment

  1. amazing news looks like gut microbiota will help identify new ways to treat gut related disease like cancer and autoimmune diseases and even neurodegenerative diseases

Leave a Reply

Translate »