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Researchers begin to map epigenetic methylation in specific cancer drug resistance.

A team of researchers led by Duke Cancer Institute have identified key events that prompt certain cancer cells to develop resistance to otherwise lethal therapies.  By mapping the points of epigenetic methylation that cells of melanoma, breast cancer and a blood cancer called myelofibrosis use to become resistant to drugs, the researchers now have much better targets for blocking those pathways and keeping current therapies effective.  The findings are published in two papers in the journal Science Signaling.

Clinical resistance to anticancer therapies is a major problem.  The most logical way to solve the problem is to understand why tumour cells become resistant to drugs, and develop strategies to thwart these processes.  In the current studies, the team developed a screening technology that allows researchers to quickly identify the routes cells can use to become resistant, and using that information, the group were able to show that these mechanisms seen in the laboratory are actually also occurring in patients’ tumours.

The team conducted a broad survey of the known cell-signaling pathways that, when activated, have the potential to trigger resistance to drugs. Using this screening technology, they were able to corroborate the results of earlier drug-resistance studies, while also finding new pathways that had not previously been described.  The new mechanisms  team identified in the laboratory were also clinically relevant, appearing in tumour cells from patients who had grown resistant to therapies.

Interestingly, the mechanisms are quite similar among all three of the cancer types.  In breast cancer and melanoma, our findings suggest the same Notch-1 pathway as a potential driver of resistance to a wide array of targeted therapies, a role that has not been widely acknowledged previously.

The team state that in myelofibrosis, they tracked a pair of separate signaling pathways downstream of an important signaling molecule called RAS. When activated, these pathways promote resistance to current standard-of-care targeted drugs by suppressing cell death. In the second paper, the researchers suggest that targeting the pathways downstream of RAS may sustain the potency of current therapies.

Together, these findings improve the medical community’s ability to stratify patients into groups more and less likely to respond to therapy and design drug combinations that work together to block or delay resistance.

Source:  Duke School of Medicine

 

Analysis of Notch1 pathway members and EMT markers in human breast cancer patients.  Correlation plot of Notch1, Notch1 pathway, Notch1 target genes, and dedifferentiation markers in luminal B breast tumors.  Systematic identification of signaling pathways with potential to confer anticancer drug resistance.  Wood et al 2014.
Analysis of Notch1 pathway members and EMT markers in human breast cancer patients. Correlation plot of Notch1, Notch1 pathway, Notch1
target genes, and dedifferentiation markers in luminal B breast tumors. Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Wood et al 2014.

 

 

 

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Michelle Petersen is the founder of Healthinnovations, having worked in the health and science industry for over 21 years, which includes tenure within the NHS and Oxford University. Healthinnovations is a publication that has reported on, influenced, and researched current and future innovations in health for the past decade.

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An avid campaigner in the fight against child sex abuse and trafficking, Michelle is a passionate humanist striving for a better quality of life for all humans by helping to provide traction for new technologies and techniques within healthcare.

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