Wound repair is an important aspect of physiology, and disruption of this process can result in a number of defects involving wound healing, chronic ulceration and scarring. A scar on a person’s skin may look bad, however, it can become life-threatening with a heart attack where a scar is formed on the heart. Now, a study from researchers at Ohio State University has pinpointed the human gene which helps to regulate wound healing and control scarring. The team state that their findings could help heal open wounds, decrease recovery time after surgery and reduce the spread of infections. The study published in The Journal Of Biological Chemistry.
Earlier studies from the lab show that the protein, Mitsugumin 53 (MG53) encoded by the TRIM72 gene, is an essential component of the cell membrane repair machinery. All animals carry this gene and it’s almost identical no matter which species. Even simple actions, like walking or typing, will cause injuries to the body. Usually this isn’t a problem because MG53, a muscle-specific TRIM family protein, can make repairs before there’s any serious harm. Despite all this MG53 is a membrane repair gene whose role in wound healing has not been studied. The current study shows the functional role of MG53 in the modulation of wound healing and scarring.
The current study utilised genetically engineered mice without the gene that makes MG53 to see what would happen without its healing capabilities. Results show that the mice lacking MG53 had difficulty recovering from injury, because of their compromised repair capacity; their heart would not function well under stress conditions.
Data findings show that MG53 works in tandem with another protein called TGF Beta, a type of cytokine protein that also heals wounds, however, the healing process happens so quickly that it causes scars. The group state, therefore, if a person has more TGF Beta in their bloodstream than MG53, the person will scar easily.
The team surmise that their study establishes MG53 as facilitator of injury repair and inhibitor of myofibroblast differentiation during wound healing. For the future, the researchers state that their goal is to develop a therapy that will inhibit TGF Beta and promote MG53. They go on to add that medical professionals can use the therapy during procedures to promote quick, scarless healing.
Michelle Petersen is the founder of Healthinnovations, having worked in the health and science industry for over 21 years, which includes tenure within the NHS and Oxford University. Healthinnovations is a publication that has reported on, influenced, and researched current and future innovations in health for the past decade.
Michelle has been picked up as an expert writer for Informa publisher’s Clinical Trials community, as well as being listed as a blog source by the world’s leading medical journals, including the acclaimed Nature-Springer journal series.
Healthinnovations is currently indexed by the trusted Altmetric and PlumX metrics systems, respectively, as a blog source for published research globally. Healthinnovations is also featured in the world-renowned BioPortfolio, BioPortfolio.com, the life science, pharmaceutical and healthcare portal.
Most recently the Texas A&M University covered The Top 10 Healthinnovations series on their site with distinguished Professor Stephen Maren calling the inclusion of himself and his team on the list a reflection of “the hard work and dedication of my students and trainees”.
Michelle Petersen’s copy was used in the highly successful marketing campaign for the mega-hit film ‘Jumanji: The Next Level, starring Jack Black, Karen Gilian, Kevin Hart and Dwayne ‘The Rock’ Johnson. Michelle Petersen’s copywriting was part of the film’s coverage by the Republic TV network. Republic TV is the most-watched English language TV channel in India since its inception in 2017.
An avid campaigner in the fight against child sex abuse and trafficking, Michelle is a passionate humanist striving for a better quality of life for all humans by helping to provide traction for new technologies and techniques within healthcare.